Repurposing benzbromarone as antifolate to develop novel antifungal therapy for Candida albicans벤즈브로마론을 항엽산으로 용도 변경하여 칸디다 알비칸스에 대한 새로운 항진균 요법 개발Article Published on 2022-06-182022-09-11 Journal: Journal of molecular modeling [Category] 신약개발, [키워드] Absorption Antifungal antifungal therapy approach Benzbromarone Biosynthesis Candida Candida albican Candida albicans candidiasis coenzyme complex complications Computational drug COVID-19 COVID-19 patient COVID-19 patients develop DHFR dihydrofolate drug resistance Effect enzyme folate Folic acid followed by fungal Fungal infection fungal infections Human identify Immunocompromised Infection inhibitor involved macromolecular Mild molecular molecular docking Mortality nucleotides Probability problem problems repurposing required responsible resulting Severe infection severe infections symptomatic systemic effect systemic effects tetrahydrofolate therapy toxic effects Treatment Virtual screening White-fungus. [DOI] 10.1007/s00894-022-05185-w PMC 바로가기 [Article Type] Article
Synergistic interactions of repurposed drugs that inhibit Nsp1, a major virulence factor for COVID-19COVID-19의 주요 독성 인자인 Nsp1을 억제하는 용도 변경 약물의 시너지 상호 작용Article Published on 2022-06-172022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 변종, 치료기술, 치료법, 치료제, [키워드] C-terminal Combination Compound COVID-19 Cytopathic effect expressed functional inhibit inhibited Interaction lung cells Montelukast Multiple Mutation nsp1 Ponatinib Protein Repurposed drug reversed Rilpivirine SARS-CoV-2 genome significantly synergistic the SARS-CoV-2 genome toxic effect toxic effects treat Virtual screening virulence virulence factor was used [DOI] 10.1038/s41598-022-14194-x PMC 바로가기 [Article Type] Article
Benzo[ a]pyrene-Environmental Occurrence, Human Exposure, and Mechanisms of Toxicity벤조[a]피렌-환경 발생, 인체 노출 및 독성 메커니즘Review Published on 2022-06-062022-09-11 Journal: International Journal of Molecular Sciences [Category] 유전자 메커니즘, [키워드] aromatic hydrocarbon association benzo[a]pyrene carcinogenic carcinogenicity cause cigarette smoke concerning COVID-19 pandemic cytochrome P450 determine DNA epoxy Evidence exhibit exposure exposure to expressed facilitate genotoxicity Human impairment involved mechanism metabolism multiplication Mutation neurotoxic Occurrence organism P450 polycyclic polycyclic aromatic hydrocarbons. polymorphism pyrene receptor sensitivity Soil Surface water teratogenic toxic effect toxic effects Toxicity turn viruses water widespread xenobiotics [DOI] 10.3390/ijms23116348 PMC 바로가기 [Article Type] Review
Generation of environmental persistent free radicals (EPFRs) enhances ecotoxicological effects of the disposable face mask waste with the COVID-19 pandemic환경 지속성 자유 라디칼(EPFR)의 생성은 COVID-19 전염병으로 일회용 안면 마스크 폐기물의 생태독성 효과를 향상시킵니다Article Published on 2022-05-152022-09-11 Journal: Environmental pollution (Barking, Essex : 1987) [Category] COVID19(2023년), SARS, 치료기술, [키워드] acetophenone acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 BENZOTHIAZOLE bisphenol butylphenol carbon characteristic contribute coronavirus COVID-19 COVID-19 pandemic cytotoxicity dominant dramatic increase Effect ENhance Environmentally persistent free radicals (EPFRs) exposure to Face mask free radical generate Generation Health risk Heavy metals higher risk highlight in vitro Leachate Mask microplastics Microplastics (MPs) mixture N95 respirator N95 respirators oxidative stress oxygen pandemic phthalide plastic Plastic face masks (DPFs). plasticizer Polypropylene produced risk Risk assessment SARS-CoV-2 severe acute respiratory syndrome Coronavirus solvent surgical TERT tested toxic effects Toxicity water [DOI] 10.1016/j.envpol.2022.119019 PMC 바로가기 [Article Type] Article
The nanocomposites designs of phytomolecules from medicinal and aromatic plants: promising anticancer-antiviral applicationsReview Published on 2022-01-292022-10-28 Journal: Beni-Suef University Journal of Basic and Applied Sciences [Category] COVID-19, [키워드] Abstract analyzed anticancer Anticancer-antiviral activity antiviral agent Antiviral effect approach Beta vulgaris Cancer cancer treatment clove component Compound contribute Crocus curative disease doses drugs Effect effective Effects Efficacy elevated help Herbal illness investigation Lavender molecular mechanism Phytonanocomposite Red beet Research researcher Saffron Scientific community Syzygium these compound toxic effects virus [DOI] 10.1186/s43088-022-00198-z PMC 바로가기 [Article Type] Review
Regulation of gliotoxin biosynthesis and protection in Aspergillus species아스 페르 길 루스 종에서의 글리 톡신 생합성 및 보호의 조절Research Article Published on 2022-01-182022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Analysis approach aspergillosis Aspergillus Aspergillus fumigatus Aspergillus oryzae best cause colonisation component conserved disease Disease progression enzyme expresse expression expression of gene expression pattern facilitate fungal Genes genetic determinant genetic determinants Genome Glia homolog homologs human immune response identify Immune cell impair include involved kojic acid mechanism metabolism modulated mycotoxin negative regulation neutralising nidulan nidulans observé occur Occurrence pathogenicity producing regulate required responses RNA-sequencing screened secrete secretion sensitivity significantly sulfur Taking TFS toxic effect toxic effects transcription factor transcription factors transcriptional transcriptional response virulence [DOI] 10.1371/journal.pgen.1009965 PMC 바로가기 [Article Type] Research Article
Antimicrobial and Antiviral (SARS-CoV-2) Potential of Cannabinoids and Cannabis sativa : A Comprehensive ReviewReview Published on 2021-11-282022-10-30 Journal: Molecules [Category] COVID-19, SARS, [키워드] ACE2 receptor Activation anti-inflammatory compound antibiotic Antibiotic resistance Antibiotics antimicrobial antimicrobial agent antimicrobial resistance Antiviral binding pocket cannabinoid cannabis cellular Compound Comprehensive conformation coronavirus disease COVID-19 downregulating drug candidate Drug discovery Efficacy enzyme food-borne Health Host in viral M pro Participants Pathogens plant pathogen Potential produced recent Replication review SARS-CoV-2 Secondary metabolism therapeutic therapeutic potential TMPRSS2 toxic effects Transcription Treatment Trial viral entry WHO’ [DOI] 10.3390/molecules26237216 PMC 바로가기 [Article Type] Review
Antihypertensive drug treatment and susceptibility to SARS-CoV-2 infection in human PSC-derived cardiomyocytes and primary endothelial cells인간 PSC 유래 심근세포 및 1차 내피 세포에서 항고혈압 약물 치료 및 SARS-CoV-2 감염에 대한 감수성Article Published on 2021-10-122022-09-11 Journal: Stem Cell Reports [Category] SARS, 유전자 메커니즘, [키워드] ACE2 ACEi acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 Alter angiotensin angiotensin receptor blocker angiotensin-converting enzyme 2 angiotensin-converting enzyme inhibitor Antihypertensive drug antihypertensive medication ARB Cell cell type Coronavirus-2 COVID-19 drug treatment endothelial Endothelial cell endothelial cells Enzyme inhibitor heart hPSC-derived cardiomyocytes Immunity interferon involved Lisinopril losartan MAPK medications membrane-bound mitogen mitogen-activated protein kinase modulate multicenter trials Necrosis NF-κB not affect nuclear pathogenicity Pathways Protein protein coding gene protein coding genes protein kinase receptor receptor blocker RNA RNA sequencing SARS-CoV-2 SARS-COV-2 infection Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 signaling pathways significant difference significant differences stem cells stem cells. susceptibility therapy TNF toxic effect toxic effects Transcriptome transcriptome change transcriptome changes Treatment Tumor tumor necrosis tumor necrosis factor [DOI] 10.1016/j.stemcr.2021.08.018 PMC 바로가기 [Article Type] Article
Spike Proteins of SARS-CoV-2 Induce Pathological Changes in Molecular Delivery and Metabolic Function in the Brain Endothelial CellsSARS-COV-2의 스파이크 단백질은 뇌 내피 세포에서 분자 전달 및 대사 기능에서 병리학 적 변화를 유도한다.Article Published on 2021-10-082022-09-01 Journal: Viruses [Category] MERS, SARS, 진단, [키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus angiotensin angiotensin converting enzyme angiotensin converting enzyme 2 BBB Blood–brain barrier Brain cause change changes in component components coronavirus coronavirus disease COVID-19 delivery dextran drastic Effect Endothelial cell endothelial cells enzyme Express function functional host cells induce infected with SARS-CoV-2 infecting infectious agent infectious agents marker mechanism metabolic metabolic function metabolism mitochondrial molecular neurological sign neurological signs Neurological symptom Neurological symptoms pathogenic pathological pathological mechanism permeability physiological RBD recent receptor Receptor-binding domain respiratory S1 domain SARS-CoV-2 SARS-CoV-2 spike protein severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 shown spike Spike protein the receptor-binding domain toxic effect toxic effects Transferrin Treatment trimer was increased [DOI] 10.3390/v13102021 PMC 바로가기 [Article Type] Article
7-Ketocholesterol: Effects on viral infections and hypothetical contribution in COVID-197-케토콜레스테롤: 바이러스 감염에 미치는 영향 및 COVID-19에 대한 가설적 기여Review Published on 2021-09-012022-09-11 Journal: The Journal of steroid biochemistry and molecular [Category] MERS, 바이오마커, 치료제, [키워드] 7-Ketocholesterol activate activities activity acute respiratory distress acute respiratory distress syndrome adjuvant adjuvant therapies adjuvant therapy affected Age-related macular degeneration alveolar cells Alzheimer's disease Anti-viral antiviral activity Apoptosis appear assumed auto-oxidation autophagy Biomarker cancers cardiovascular diseases cell death cholesterol chronic inflammatory bowel diseases concentrations contribute contributing to COVID-19 COVID-19 patients Deleterious density disease Diseases Effect food hypothetical Inflammatory bowel disease inflammatory bowel diseases involved macular degeneration outcome Oxidation oxidized oxysterol Oxysterols pathophysiology pro-inflammatory produced promote provided recent respiratory distress Respiratory distress syndrome resulting SARS-CoV-2 serum shown side chain significantly suggested syndrome toxic effect toxic effects Viral Viral diseases viral diseases. viral infection [DOI] 10.1016/j.jsbmb.2021.105939 PMC 바로가기 [Article Type] Review